Aneuploid abortion correlates positively with MAD1 overexpression and miR-125b down-regulation

BACKGROUND: Aneuploidy is the most frequent cause of early-embryo abortion. Any defect in chromosome segregation would fail to satisfy the spindle assembly checkpoint (SAC) during mitosis, halting metaphase and causing aneuploidy. The mitotic checkpoint complex (MCC), comprising MAD1, MAD2, Cdc20, B...

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Detalhes bibliográficos
Publicado no:Mol Cytogenet
Main Authors: Zhao, Juan, Li, Hui, Chen, Guangxin, Du, Lijun, Xu, Peiyan, Zhang, Xiaoli, Xie, Min, Cao, Tiansheng, Li, Haibo
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2021
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8074413/
https://ncbi.nlm.nih.gov/pubmed/33902659
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13039-021-00538-1
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