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Aneuploid abortion correlates positively with MAD1 overexpression and miR-125b down-regulation
BACKGROUND: Aneuploidy is the most frequent cause of early-embryo abortion. Any defect in chromosome segregation would fail to satisfy the spindle assembly checkpoint (SAC) during mitosis, halting metaphase and causing aneuploidy. The mitotic checkpoint complex (MCC), comprising MAD1, MAD2, Cdc20, B...
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| Veröffentlicht in: | Mol Cytogenet |
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| Hauptverfasser: | , , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
BioMed Central
2021
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8074413/ https://ncbi.nlm.nih.gov/pubmed/33902659 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13039-021-00538-1 |
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