Dysregulated miR-155 and miR-125b Are Related to Impaired B-cell Responses in Down Syndrome

Children with Down Syndrome (DS) suffer from immune deficiency with a severe reduction in switched memory B cells (MBCs) and poor response to vaccination. Chromosome 21 (HSA21) encodes two microRNAs (miRs), miR-125b, and miR-155, that regulate B-cell responses. We studied B- and T- cell subpopulatio...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Farroni, Chiara, Marasco, Emiliano, Marcellini, Valentina, Giorda, Ezio, Valentini, Diletta, Petrini, Stefania, D'Oria, Valentina, Pezzullo, Marco, Cascioli, Simona, Scarsella, Marco, Ugazio, Alberto G., De Vincentiis, Giovanni C., Grimsholm, Ola, Carsetti, Rita
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6255899/
https://ncbi.nlm.nih.gov/pubmed/30515165
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.02683
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