Response to Hypomethylating Agents in Myelodysplastic Syndrome Is Associated With Emergence of Novel TCR Clonotypes

Aberrant T-cell function is implicated in the pathogenesis of myelodysplastic syndrome (MDS). Monitoring the T-cell receptor (TCR) repertoire can provide insights into T-cell adaptive immunity. Previous studies found skewed TCR repertoires in MDS compared to healthy patients; however these studies t...

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Dettagli Bibliografici
Pubblicato in:Front Immunol
Autori principali: Abbas, Hussein A., Reville, Patrick K., Jiang, Xianli, Yang, Hui, Reuben, Alexandre, Im, Jin Seon, Little, Latasha, Sinson, Jefferson C., Chen, Ken, Futreal, Andrew, Garcia-Manero, Guillermo
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2021
Soggetti:
Immunology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8072464/
https://ncbi.nlm.nih.gov/pubmed/33912187
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2021.659625
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