Impact of the number of mutations in survival and response outcomes to hypomethylating agents in patients with myelodysplastic syndromes or myelodysplastic/myeloproliferative neoplasms

The prognostic and predictive value of sequencing analysis in myelodysplastic syndromes (MDS) has not been fully integrated into clinical practice. We performed whole exome sequencing (WES) of bone marrow samples from 83 patients with MDS and 31 with MDS/MPN identifying 218 driver mutations in 31 ge...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Montalban-Bravo, Guillermo, Takahashi, Koichi, Patel, Keyur, Wang, Feng, Xingzhi, Song, Nogueras, Graciela M., Huang, Xuelin, Pierola, Ana Alfonso, Jabbour, Elias, Colla, Simona, Gañan-Gomez, Irene, Borthakur, Gautham, Daver, Naval, Estrov, Zeev, Kadia, Tapan, Pemmaraju, Naveen, Ravandi, Farhad, Bueso-Ramos, Carlos, Chamseddine, Ali, Konopleva, Marina, Zhang, Jianhua, Kantarjian, Hagop, Futreal, Andrew, Garcia-Manero, Guillermo
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2018
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5839396/
https://ncbi.nlm.nih.gov/pubmed/29515765
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.23882
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