Impact of the number of mutations in survival and response outcomes to hypomethylating agents in patients with myelodysplastic syndromes or myelodysplastic/myeloproliferative neoplasms

The prognostic and predictive value of sequencing analysis in myelodysplastic syndromes (MDS) has not been fully integrated into clinical practice. We performed whole exome sequencing (WES) of bone marrow samples from 83 patients with MDS and 31 with MDS/MPN identifying 218 driver mutations in 31 ge...

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Published in:Oncotarget
Main Authors: Montalban-Bravo, Guillermo, Takahashi, Koichi, Patel, Keyur, Wang, Feng, Xingzhi, Song, Nogueras, Graciela M., Huang, Xuelin, Pierola, Ana Alfonso, Jabbour, Elias, Colla, Simona, Gañan-Gomez, Irene, Borthakur, Gautham, Daver, Naval, Estrov, Zeev, Kadia, Tapan, Pemmaraju, Naveen, Ravandi, Farhad, Bueso-Ramos, Carlos, Chamseddine, Ali, Konopleva, Marina, Zhang, Jianhua, Kantarjian, Hagop, Futreal, Andrew, Garcia-Manero, Guillermo
Format: Artigo
Language:Inglês
Published: Impact Journals LLC 2018
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Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5839396/
https://ncbi.nlm.nih.gov/pubmed/29515765
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.23882
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