A G316A Polymorphism in the Ornithine Decarboxylase Gene Promoter Modulates MYCN-Driven Childhood Neuroblastoma

SIMPLE SUMMARY: Neuroblastoma is a devasting childhood cancer in which multiple copies (amplification) of the cancer-causing gene MYCN strongly predict poor outcome. Neuroblastomas are reliant on high levels of cellular components called polyamines for their growth and malignant behavior, and the ge...

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Udgivet i:Cancers (Basel)
Main Authors: Gamble, Laura D., Purgato, Stefania, Henderson, Michelle J., Di Giacomo, Simone, Russell, Amanda J., Pigini, Paolo, Murray, Jayne, Valli, Emanuele, Milazzo, Giorgio, Giorgi, Federico M., Cowley, Mark, Ashton, Lesley J., Bhalshankar, Jaydutt, Schleiermacher, Gudrun, Rihani, Ali, Van Maerken, Tom, Vandesompele, Jo, Speleman, Frank, Versteeg, Rogier, Koster, Jan, Eggert, Angelika, Noguera, Rosa, Stallings, Raymond L., Tonini, Gian Paolo, Fong, Kwun, Vaksman, Zalman, Diskin, Sharon J., Maris, John M., London, Wendy B., Marshall, Glenn M., Ziegler, David S., Hogarty, Michael D., Perini, Giovanni, Norris, Murray D., Haber, Michelle
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8069650/
https://ncbi.nlm.nih.gov/pubmed/33918978
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers13081807
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