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Comprehensive characterization of Alu‐mediated breakpoints in germline VHL gene deletions and rearrangements in patients from 71 VHL families

Von Hippel‐Lindau (VHL) is a hereditary multisystem disorder caused by germline alterations in the VHL gene. VHL patients are at risk for benign as well as malignant lesions in multiple organs including kidney, adrenal, pancreas, the central nervous system, retina, endolymphatic sac of the ear, epid...

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Détails bibliographiques
Publié dans:Hum Mutat
Auteurs principaux: Vocke, Cathy D., Ricketts, Christopher J., Schmidt, Laura S., Ball, Mark W., Middelton, Lindsay A., Zbar, Berton, Linehan, W. Marston
Format: Artigo
Langue:Inglês
Publié: John Wiley and Sons Inc. 2021
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8068631/
https://ncbi.nlm.nih.gov/pubmed/33675279
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/humu.24194
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