Biopharmaceutics of Topical Ophthalmic Suspensions: Importance of Viscosity and Particle Size in Ocular Absorption of Indomethacin

Eye drops of poorly soluble drugs are frequently formulated as suspensions. Bioavailability of suspended drug depends on the retention and dissolution of drug particles in the tear fluid, but these factors are still poorly understood. We investigated seven ocular indomethacin suspensions (experiment...

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Udgivet i:Pharmaceutics
Main Authors: Toropainen, Elisa, Fraser-Miller, Sara J., Novakovic, Dunja, Del Amo, Eva M., Vellonen, Kati-Sisko, Ruponen, Marika, Viitala, Tapani, Korhonen, Ossi, Auriola, Seppo, Hellinen, Laura, Reinisalo, Mika, Tengvall, Unni, Choi, Stephanie, Absar, Mohammad, Strachan, Clare, Urtti, Arto
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8067094/
https://ncbi.nlm.nih.gov/pubmed/33810564
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/pharmaceutics13040452
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