Biopharmaceutics of Topical Ophthalmic Suspensions: Importance of Viscosity and Particle Size in Ocular Absorption of Indomethacin

Eye drops of poorly soluble drugs are frequently formulated as suspensions. Bioavailability of suspended drug depends on the retention and dissolution of drug particles in the tear fluid, but these factors are still poorly understood. We investigated seven ocular indomethacin suspensions (experiment...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Pharmaceutics
Prif Awduron: Toropainen, Elisa, Fraser-Miller, Sara J., Novakovic, Dunja, Del Amo, Eva M., Vellonen, Kati-Sisko, Ruponen, Marika, Viitala, Tapani, Korhonen, Ossi, Auriola, Seppo, Hellinen, Laura, Reinisalo, Mika, Tengvall, Unni, Choi, Stephanie, Absar, Mohammad, Strachan, Clare, Urtti, Arto
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: MDPI 2021
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC8067094/
https://ncbi.nlm.nih.gov/pubmed/33810564
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/pharmaceutics13040452
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