Age and insulin-like growth factor-1 impact PCNA monoubiquitination in UVB-irradiated human skin

Nonmelanoma skin cancers occur primarily in individuals over the age of 60 and are characterized by an abundance of ultraviolet (UV) signature mutations in keratinocyte DNA. Though geriatric skin removes UV photoproducts from DNA less efficiently than young adult skin, it is not known whether the ut...

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Dettagli Bibliografici
Pubblicato in:J Biol Chem
Autori principali: Hutcherson, Rebekah J., Gabbard, Ryan D., Castellanos, Amber J., Travers, Jeffrey B., Kemp, Michael G.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2021
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8065225/
https://ncbi.nlm.nih.gov/pubmed/33753168
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbc.2021.100570
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