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Spironolactone depletes the XPB protein and inhibits DNA damage responses in UVB-irradiated human skin
UVB wavelengths of light induce the formation of photoproducts in genomic DNA that are potentially mutagenic and detrimental to epidermal cell function. Interestingly, the mineralocorticoid and androgen receptor antagonist spironolactone (SP) was recently identified as an inhibitor of UV photoproduc...
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| Yayımlandı: | J Invest Dermatol |
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| Asıl Yazarlar: | , , , , , , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
2018
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6342635/ https://ncbi.nlm.nih.gov/pubmed/30227140 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jid.2018.07.039 |
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