Spironolactone depletes the XPB protein and inhibits DNA damage responses in UVB-irradiated human skin

UVB wavelengths of light induce the formation of photoproducts in genomic DNA that are potentially mutagenic and detrimental to epidermal cell function. Interestingly, the mineralocorticoid and androgen receptor antagonist spironolactone (SP) was recently identified as an inhibitor of UV photoproduc...

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Detaylı Bibliyografya
Yayımlandı:J Invest Dermatol
Asıl Yazarlar: Kemp, Michael G., Krishnamurthy, Smita, Kent, Michael N., Schumacher, David L., Sharma, Priyanka, Excoffon, Katherine J.D.A., Travers, Jeffrey B.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2018
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6342635/
https://ncbi.nlm.nih.gov/pubmed/30227140
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jid.2018.07.039
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