Spironolactone depletes the XPB protein and inhibits DNA damage responses in UVB-irradiated human skin

UVB wavelengths of light induce the formation of photoproducts in genomic DNA that are potentially mutagenic and detrimental to epidermal cell function. Interestingly, the mineralocorticoid and androgen receptor antagonist spironolactone (SP) was recently identified as an inhibitor of UV photoproduc...

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Publicado en:J Invest Dermatol
Autores principales: Kemp, Michael G., Krishnamurthy, Smita, Kent, Michael N., Schumacher, David L., Sharma, Priyanka, Excoffon, Katherine J.D.A., Travers, Jeffrey B.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2018
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6342635/
https://ncbi.nlm.nih.gov/pubmed/30227140
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jid.2018.07.039
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