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Glucose-induced insulin secretion in isolated human islets: Does it truly reflect β-cell function in vivo?

BACKGROUND: Diabetes always involves variable degrees of β-cell demise and malfunction leading to insufficient insulin secretion. Besides clinical investigations, many research projects used rodent islets to study various facets of β-cell pathophysiology. Their important contributions laid the found...

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Bibliografische gegevens
Gepubliceerd in:Mol Metab
Hoofdauteur: Henquin, Jean-Claude
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Elsevier 2021
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8065218/
https://ncbi.nlm.nih.gov/pubmed/33737253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2021.101212
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