CRISPR-based genome editing in primary human pancreatic islet cells

Gene targeting studies in primary human islets could advance our understanding of mechanisms driving diabetes pathogenesis. Here, we demonstrate successful genome editing in primary human islets using clustered regularly interspaced short palindromic repeats (CRISPR) and CRISPR-associated protein 9...

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Publicat a:Nat Commun
Autors principals: Bevacqua, Romina J., Dai, Xiaoqing, Lam, Jonathan Y., Gu, Xueying, Friedlander, Mollie S. H., Tellez, Krissie, Miguel-Escalada, Irene, Bonàs-Guarch, Silvia, Atla, Goutham, Zhao, Weichen, Kim, Seung Hyun, Dominguez, Antonia A., Qi, Lei S., Ferrer, Jorge, MacDonald, Patrick E., Kim, Seung K.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2021
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8065166/
https://ncbi.nlm.nih.gov/pubmed/33893274
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-22651-w
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