CRISPR-based genome editing in primary human pancreatic islet cells

Gene targeting studies in primary human islets could advance our understanding of mechanisms driving diabetes pathogenesis. Here, we demonstrate successful genome editing in primary human islets using clustered regularly interspaced short palindromic repeats (CRISPR) and CRISPR-associated protein 9...

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Gepubliceerd in:Nat Commun
Hoofdauteurs: Bevacqua, Romina J., Dai, Xiaoqing, Lam, Jonathan Y., Gu, Xueying, Friedlander, Mollie S. H., Tellez, Krissie, Miguel-Escalada, Irene, Bonàs-Guarch, Silvia, Atla, Goutham, Zhao, Weichen, Kim, Seung Hyun, Dominguez, Antonia A., Qi, Lei S., Ferrer, Jorge, MacDonald, Patrick E., Kim, Seung K.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group UK 2021
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8065166/
https://ncbi.nlm.nih.gov/pubmed/33893274
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-22651-w
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