Evaluation of Hsp90 and mTOR inhibitors as potential drugs for the treatment of TSC1/TSC2 deficient cancer

Inactivating mutations in either TSC1 or TSC2 cause Tuberous Sclerosis Complex, an autosomal dominant disorder, characterized by multi-system tumor and hamartoma development. Mutation and loss of function of TSC1 and/or TSC2 also occur in a variety of sporadic cancers, and rapamycin and related drug...

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Bibliographic Details
Published in:PLoS One
Main Authors: Mrozek, Evelyn M., Bajaj, Vineeta, Guo, Yanan, Malinowska, Izabela A., Zhang, Jianming, Kwiatkowski, David J.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2021
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8064564/
https://ncbi.nlm.nih.gov/pubmed/33891611
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0248380
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