Optimized experimental pre-treatment strategy for temporary inhibition of islet amyloid polypeptide aggregation

Islet amyloid polypeptide (IAPP) is a neuroendocrine hormone from pancreatic β-cells. Misfolded, aggregated IAPP is believed to be toxic to islet cells and amyloid deposits in the pancreas are pathological hallmarks of type 2 diabetes. Rapid fibrillization of this peptide makes it difficult to study...

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Bibliographic Details
Published in:Biochem Biophys Rep
Main Authors: Ferguson, Madison Q., DeRosa, Maria C.
Format: Artigo
Language:Inglês
Published: Elsevier 2021
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Short Communication
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8063701/
https://ncbi.nlm.nih.gov/pubmed/33912690
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrep.2021.100964
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