The Molecular Basis of Distinct Aggregation Pathways of Islet Amyloid Polypeptide

Abnormal aggregation of islet amyloid polypeptide (IAPP) into amyloid fibrils is a hallmark of type 2 diabetes. In this study, we investigated the initial oligomerization and subsequent addition of monomers to growing aggregates of human IAPP at the residue-specific level using NMR, atomic force mic...

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Detalhes bibliográficos
Main Authors: Wei, Lei, Jiang, Ping, Xu, Weixin, Li, Hai, Zhang, Hua, Yan, Liangyu, Chan-Park, Mary B., Liu, Xue-Wei, Tang, Kai, Mu, Yuguang, Pervushin, Konstantin
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3057848/
https://ncbi.nlm.nih.gov/pubmed/21148563
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.166678
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