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Temperature Based Process Characterization of Pharmaceutical Freeze-Thaw Operations

In biopharmaceutical production processes, freeze-thaw operations are used to ensure product integrity during long hold times, but they also introduce additional stresses such as freeze concentration gradients that might lead to a loss of protein activity. Process characterization of freeze-thaw ope...

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Detalhes bibliográficos
Publicado no:Front Bioeng Biotechnol
Principais autores: Weber, Dennis, Hubbuch, Jürgen
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8062970/
https://ncbi.nlm.nih.gov/pubmed/33898399
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fbioe.2021.617770
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