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α-Crystallins in the vertebrate eye lens: Complex oligomers and molecular chaperones

α-crystallins are small heat-shock proteins that act as holdase chaperones. In humans, αA is expressed only in the eye lens, while αB is found in many tissues. α-crystallins have a central domain flanked by flexible extensions and form dynamic, heterogenous oligomers. Structural models show that bot...

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Detalhes bibliográficos
Publicado no:Annu Rev Phys Chem
Main Authors: Sprague-Piercy, Marc A., Rocha, Megan A., Kwok, Ashley O., Martin, Rachel W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8062273/
https://ncbi.nlm.nih.gov/pubmed/33321054
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1146/annurev-physchem-090419-121428
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