DNA methylation patterns expose variations in enhancer-chromatin modifications during embryonic stem cell differentiation

In mammals, cellular identity is defined through strict regulation of chromatin modifications and DNA methylation that control gene expression. Methylation of cytosines at CpG sites in the genome is mainly associated with suppression; however, the reason for enhancer-specific methylation is not full...

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Udgivet i:PLoS Genet
Main Authors: Alajem, Adi, Roth, Hava, Ratgauzer, Sofia, Bavli, Danny, Motzik, Alex, Lahav, Shlomtzion, Peled, Itay, Ram, Oren
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2021
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Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8062104/
https://ncbi.nlm.nih.gov/pubmed/33844685
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1009498
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