Delineating the heterogeneity of matrix-directed differentiation toward soft and stiff tissue lineages via single-cell profiling

Mesenchymal stromal/stem cells (MSCs) form a heterogeneous population of multipotent progenitors that contribute to tissue regeneration and homeostasis. MSCs assess extracellular elasticity by probing resistance to applied forces via adhesion, cytoskeletal, and nuclear mechanotransducers that direct...

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Dettagli Bibliografici
Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Brielle, Shlomi, Bavli, Danny, Motzik, Alex, Kan-Tor, Yoav, Sun, Xue, Kozulin, Chen, Avni, Batia, Ram, Oren, Buxboim, Amnon
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2021
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8126831/
https://ncbi.nlm.nih.gov/pubmed/33941688
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2016322118
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