Association of Dual LRRK2 G2019S and GBA Variations With Parkinson Disease Progression

IMPORTANCE: Despite a hypothesis that harboring a leucine-rich repeat kinase 2(LRRK2) G2019S variation and a glucocerebrosidase (GBA) variant would have a combined deleterious association with disease pathogenesis, milder clinical phenotypes have been reported in dual LRRK2 and GBA variations Parkin...

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Vydáno v:JAMA Netw Open
Hlavní autoři: Ortega, Roberto A., Wang, Cuiling, Raymond, Deborah, Bryant, Nicole, Scherzer, Clemens R., Thaler, Avner, Alcalay, Roy N., West, Andrew B., Mirelman, Anat, Kuras, Yuliya, Marder, Karen S., Giladi, Nir, Ozelius, Laurie J., Bressman, Susan B., Saunders-Pullman, Rachel
Médium: Artigo
Jazyk:Inglês
Vydáno: American Medical Association 2021
Témata:
Original Investigation
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8060834/
https://ncbi.nlm.nih.gov/pubmed/33881531
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jamanetworkopen.2021.5845
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