Association of Dual LRRK2 G2019S and GBA Variations With Parkinson Disease Progression

IMPORTANCE: Despite a hypothesis that harboring a leucine-rich repeat kinase 2(LRRK2) G2019S variation and a glucocerebrosidase (GBA) variant would have a combined deleterious association with disease pathogenesis, milder clinical phenotypes have been reported in dual LRRK2 and GBA variations Parkin...

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Pubblicato in:JAMA Netw Open
Autori principali: Ortega, Roberto A., Wang, Cuiling, Raymond, Deborah, Bryant, Nicole, Scherzer, Clemens R., Thaler, Avner, Alcalay, Roy N., West, Andrew B., Mirelman, Anat, Kuras, Yuliya, Marder, Karen S., Giladi, Nir, Ozelius, Laurie J., Bressman, Susan B., Saunders-Pullman, Rachel
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Medical Association 2021
Soggetti:
Original Investigation
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8060834/
https://ncbi.nlm.nih.gov/pubmed/33881531
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jamanetworkopen.2021.5845
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