Association of Dual LRRK2 G2019S and GBA Variations With Parkinson Disease Progression

IMPORTANCE: Despite a hypothesis that harboring a leucine-rich repeat kinase 2(LRRK2) G2019S variation and a glucocerebrosidase (GBA) variant would have a combined deleterious association with disease pathogenesis, milder clinical phenotypes have been reported in dual LRRK2 and GBA variations Parkin...

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Publicado en:JAMA Netw Open
Autores principales: Ortega, Roberto A., Wang, Cuiling, Raymond, Deborah, Bryant, Nicole, Scherzer, Clemens R., Thaler, Avner, Alcalay, Roy N., West, Andrew B., Mirelman, Anat, Kuras, Yuliya, Marder, Karen S., Giladi, Nir, Ozelius, Laurie J., Bressman, Susan B., Saunders-Pullman, Rachel
Formato: Artigo
Lenguaje:Inglês
Publicado: American Medical Association 2021
Materias:
Original Investigation
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC8060834/
https://ncbi.nlm.nih.gov/pubmed/33881531
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jamanetworkopen.2021.5845
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