Activation of von Willebrand factor via mechanical unfolding of its discontinuous autoinhibitory module

Von Willebrand factor (VWF) activates in response to shear flow to initiate hemostasis, while aberrant activation could lead to thrombosis. Above a critical shear force, the A1 domain of VWF becomes activated and captures platelets via the GPIb-IX complex. Here we show that the shear-responsive elem...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Arce, Nicholas A., Cao, Wenpeng, Brown, Alexander K., Legan, Emily R., Wilson, Moriah S., Xu, Emma-Ruoqi, Berndt, Michael C., Emsley, Jonas, Zhang, X. Frank, Li, Renhao
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8060278/
https://ncbi.nlm.nih.gov/pubmed/33883551
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-22634-x
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