Activation of von Willebrand factor via mechanical unfolding of its discontinuous autoinhibitory module

Von Willebrand factor (VWF) activates in response to shear flow to initiate hemostasis, while aberrant activation could lead to thrombosis. Above a critical shear force, the A1 domain of VWF becomes activated and captures platelets via the GPIb-IX complex. Here we show that the shear-responsive elem...

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Vydáno v:Nat Commun
Hlavní autoři: Arce, Nicholas A., Cao, Wenpeng, Brown, Alexander K., Legan, Emily R., Wilson, Moriah S., Xu, Emma-Ruoqi, Berndt, Michael C., Emsley, Jonas, Zhang, X. Frank, Li, Renhao
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2021
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8060278/
https://ncbi.nlm.nih.gov/pubmed/33883551
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-22634-x
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