Telomerase therapy attenuates cardiotoxic effects of doxorubicin

Doxorubicin is one of the most potent chemotherapeutic agents. However, its clinical use is restricted due to the severe risk of cardiotoxicity, partially attributed to elevated production of reactive oxygen species (ROS). Telomerase canonically maintains telomeres during cell division but is silenc...

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Veröffentlicht in:Mol Ther
Hauptverfasser: Chatterjee, Shambhabi, Hofer, Teresa, Costa, Alessia, Lu, Dongchao, Batkai, Sandor, Gupta, Shashi Kumar, Bolesani, Emiliano, Zweigerdt, Robert, Megias, Diego, Streckfuss-Bömeke, Katrin, Brandenberger, Christina, Thum, Thomas, Bär, Christian
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Gene & Cell Therapy 2021
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8058493/
https://ncbi.nlm.nih.gov/pubmed/33388418
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2020.12.035
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