A Stapled POL κ Peptide Targets REV1 to Inhibit Mutagenic Translesion Synthesis.

Stapled α-helical RIR (Rev1-interacting region) peptides of DNA POL κ bind more effectively to the RIR-interface of the C-terminal recruitment domain of the translesion synthesis DNA polymerase Rev1 than unstapled peptide. The tightest-binding stapled peptide translocates into cells and enhances the...

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Udgivet i:Environ Mol Mutagen
Main Authors: Chatterjee, Nimrat, D’Souza, Sanjay, Shabab, Mohammad, Harris, Cynthia A., Hilinski, Gerard J., Verdine, Gregory L., Walker, Graham C.
Format: Artigo
Sprog:Inglês
Udgivet: 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8057520/
https://ncbi.nlm.nih.gov/pubmed/32573829
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/em.22395
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