Placental disposition of eculizumab, C5 and C5‐eculizumab in two pregnancies of a woman with paroxysmal nocturnal haemoglobinuria

Eculizumab is known to cross the placenta to a limited degree, but recently therapeutic drug levels in cord blood were found in a single case. We report maternal, cord and placental levels of unbound eculizumab, C5 and C5‐eculizumab in two pregnancies of a paroxysmal nocturnal haemoglobinuria patien...

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Vydáno v:Br J Clin Pharmacol
Hlavní autoři: Eliesen, Gaby A.M., van Drongelen, Joris, van den Broek, Petra H.H., Sarlea, Andrei, van der Heijden, Olivier W.H., Langemeijer, Saskia, Greupink, Rick, Volokhina, Elena B., Russel, Frans G.M.
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2020
Témata:
Short Reports
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8056731/
https://ncbi.nlm.nih.gov/pubmed/32986871
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.14565
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