Long-term safety and efficacy of sustained eculizumab treatment in patients with paroxysmal nocturnal haemoglobinuria

Paroxysmal nocturnal haemoglobinuria (PNH) is characterized by chronic, uncontrolled complement activation resulting in elevated intravascular haemolysis and morbidities, including fatigue, dyspnoea, abdominal pain, pulmonary hypertension, thrombotic events (TEs) and chronic kidney disease (CKD). Th...

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Detalhes bibliográficos
Main Authors: Hillmen, Peter, Muus, Petra, Röth, Alexander, Elebute, Modupe O, Risitano, Antonio M, Schrezenmeier, Hubert, Szer, Jeffrey, Browne, Paul, Maciejewski, Jaroslaw P, Schubert, Jörg, Urbano-Ispizua, Alvaro, de Castro, Carlos, Socié, Gérard, Brodsky, Robert A
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2013
Assuntos:
Haematological Malignancy
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3744747/
https://ncbi.nlm.nih.gov/pubmed/23617322
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bjh.12347
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