Long-term safety and efficacy of sustained eculizumab treatment in patients with paroxysmal nocturnal haemoglobinuria

Paroxysmal nocturnal haemoglobinuria (PNH) is characterized by chronic, uncontrolled complement activation resulting in elevated intravascular haemolysis and morbidities, including fatigue, dyspnoea, abdominal pain, pulmonary hypertension, thrombotic events (TEs) and chronic kidney disease (CKD). Th...

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Dettagli Bibliografici
Autori principali: Hillmen, Peter, Muus, Petra, Röth, Alexander, Elebute, Modupe O, Risitano, Antonio M, Schrezenmeier, Hubert, Szer, Jeffrey, Browne, Paul, Maciejewski, Jaroslaw P, Schubert, Jörg, Urbano-Ispizua, Alvaro, de Castro, Carlos, Socié, Gérard, Brodsky, Robert A
Natura: Artigo
Lingua:Inglês
Pubblicazione: Blackwell Publishing Ltd 2013
Soggetti:
Haematological Malignancy
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3744747/
https://ncbi.nlm.nih.gov/pubmed/23617322
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bjh.12347
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