The Inclusion of Tolfenamic Acid into Cyclodextrins Stimulated by Microenvironmental pH Modification as a Way to Increase the Anti-Migraine Effect

PURPOSE: The poorly soluble nonsteroidal anti-inflammatory drug (NSAID), tolfenamic acid (TA), was studied to maximize its solubility, permeability through biological membranes, and pharmacological activity. METHODS: A mixture with magnesium stearate (MS) – microenvironment pH-modifier was prepared,...

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Dettagli Bibliografici
Pubblicato in:J Pain Res
Autori principali: Stasiłowicz, Anna, Tykarska, Ewa, Rosiak, Natalia, Sałat, Kinga, Furgała-Wojas, Anna, Plech, Tomasz, Lewandowska, Kornelia, Pikosz, Katarzyna, Pawłowicz, Kamil, Cielecka-Piontek, Judyta
Natura: Artigo
Lingua:Inglês
Pubblicazione: Dove 2021
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Original Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8055370/
https://ncbi.nlm.nih.gov/pubmed/33883930
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/JPR.S295795
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