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Changes in NAD and Lipid Metabolism Drive Acidosis-Induced Acute Kidney Injury

BACKGROUND: The kidney plays an important role in maintaining normal blood pH. Metabolic acidosis (MA) upregulates the pathway that mitochondria in the proximal tubule (PT) use to produce ammonia and bicarbonate from glutamine, and is associated with AKI. However, the extent to which MA causes AKI,...

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Detalhes bibliográficos
Publicado no:J Am Soc Nephrol
Main Authors: Bugarski, Milica, Ghazi, Susan, Polesel, Marcello, Martins, Joana R., Hall, Andrew M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Nephrology 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8054907/
https://ncbi.nlm.nih.gov/pubmed/33478973
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2020071003
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