Inhibition of eIF5A hypusination pathway as a new pharmacological target for stroke therapy

In eukaryotes, the polyamine pathway generates spermidine that activates the hypusination of the translation factor eukaryotic initiation factor 5A (eIF5A). Hypusinated-eIF5A modulates translation, elongation, termination and mitochondrial function. Evidence in model organisms like drosophila sugges...

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Bibliographic Details
Published in:J Cereb Blood Flow Metab
Main Authors: Bourourou, Miled, Gouix, Elsa, Melis, Nicolas, Friard, Jonas, Heurteaux, Catherine, Tauc, Michel, Blondeau, Nicolas
Format: Artigo
Language:Inglês
Published: SAGE Publications 2020
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Original Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8054730/
https://ncbi.nlm.nih.gov/pubmed/32615885
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/0271678X20928882
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