Targeting eIF5A Hypusination Prevents Anoxic Cell Death through Mitochondrial Silencing and Improves Kidney Transplant Outcome

The eukaryotic initiation factor 5A (eIF5A), which is highly conserved throughout evolution, has the unique characteristic of post-translational activation through hypusination. This modification is catalyzed by two enzymatic steps involving deoxyhypusine synthase (DHPS) and deoxyhypusine hydroxylas...

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Detalhes bibliográficos
Publicado no:J Am Soc Nephrol
Main Authors: Melis, Nicolas, Rubera, Isabelle, Cougnon, Marc, Giraud, Sébastien, Mograbi, Baharia, Belaid, Amine, Pisani, Didier F., Huber, Stephan M., Lacas-Gervais, Sandra, Fragaki, Konstantina, Blondeau, Nicolas, Vigne, Paul, Frelin, Christian, Hauet, Thierry, Duranton, Christophe, Tauc, Michel
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Nephrology 2017
Assuntos:
Basic Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5328152/
https://ncbi.nlm.nih.gov/pubmed/27612998
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2016010012
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