Inhibition of eIF5A hypusination reprogrammes metabolism and glucose handling in mouse kidney

Inhibition of the eukaryotic initiation factor 5A activation by the spermidine analogue GC7 has been shown to protect proximal cells and whole kidneys against an acute episode of ischaemia. The highlighted mechanism involves a metabolic switch from oxidative phosphorylation toward glycolysis allowin...

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Publicado no:Cell Death Dis
Main Authors: Cougnon, Marc, Carcy, Romain, Melis, Nicolas, Rubera, Isabelle, Duranton, Christophe, Dumas, Karine, Tanti, Jean-François, Pons, Catherine, Soubeiran, Nicolas, Shkreli, Marina, Hauet, Thierry, Pellerin, Luc, Giraud, Sébastien, Blondeau, Nicolas, Tauc, Michel, Pisani, Didier F.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7969969/
https://ncbi.nlm.nih.gov/pubmed/33731685
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-021-03577-z
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