Targeting eIF5A Hypusination Prevents Anoxic Cell Death through Mitochondrial Silencing and Improves Kidney Transplant Outcome

The eukaryotic initiation factor 5A (eIF5A), which is highly conserved throughout evolution, has the unique characteristic of post-translational activation through hypusination. This modification is catalyzed by two enzymatic steps involving deoxyhypusine synthase (DHPS) and deoxyhypusine hydroxylas...

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Bibliografiset tiedot
Julkaisussa:J Am Soc Nephrol
Päätekijät: Melis, Nicolas, Rubera, Isabelle, Cougnon, Marc, Giraud, Sébastien, Mograbi, Baharia, Belaid, Amine, Pisani, Didier F., Huber, Stephan M., Lacas-Gervais, Sandra, Fragaki, Konstantina, Blondeau, Nicolas, Vigne, Paul, Frelin, Christian, Hauet, Thierry, Duranton, Christophe, Tauc, Michel
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society of Nephrology 2017
Aiheet:
Basic Research
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5328152/
https://ncbi.nlm.nih.gov/pubmed/27612998
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2016010012
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