Blockade of EIF5A hypusination limits colorectal cancer growth by inhibiting MYC elongation

Eukaryotic Translation Initiation Factor 5A (EIF5A) is a translation factor regulated by hypusination, a unique posttranslational modification catalyzed by deoxyhypusine synthetase (DHPS) and deoxyhypusine hydroxylase (DOHH) starting from the polyamine spermidine. Emerging data are showing that hypu...

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Publicado no:Cell Death Dis
Main Authors: Coni, Sonia, Serrao, Silvia Maria, Yurtsever, Zuleyha Nihan, Di Magno, Laura, Bordone, Rosa, Bertani, Camilla, Licursi, Valerio, Ianniello, Zaira, Infante, Paola, Moretti, Marta, Petroni, Marialaura, Guerrieri, Francesca, Fatica, Alessandro, Macone, Alberto, De Smaele, Enrico, Di Marcotullio, Lucia, Giannini, Giuseppe, Maroder, Marella, Agostinelli, Enzo, Canettieri, Gianluca
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7729396/
https://ncbi.nlm.nih.gov/pubmed/33303756
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-020-03174-6
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