Blockade of EIF5A hypusination limits colorectal cancer growth by inhibiting MYC elongation

Eukaryotic Translation Initiation Factor 5A (EIF5A) is a translation factor regulated by hypusination, a unique posttranslational modification catalyzed by deoxyhypusine synthetase (DHPS) and deoxyhypusine hydroxylase (DOHH) starting from the polyamine spermidine. Emerging data are showing that hypu...

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Publicado en:Cell Death Dis
Autores principales: Coni, Sonia, Serrao, Silvia Maria, Yurtsever, Zuleyha Nihan, Di Magno, Laura, Bordone, Rosa, Bertani, Camilla, Licursi, Valerio, Ianniello, Zaira, Infante, Paola, Moretti, Marta, Petroni, Marialaura, Guerrieri, Francesca, Fatica, Alessandro, Macone, Alberto, De Smaele, Enrico, Di Marcotullio, Lucia, Giannini, Giuseppe, Maroder, Marella, Agostinelli, Enzo, Canettieri, Gianluca
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group UK 2020
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7729396/
https://ncbi.nlm.nih.gov/pubmed/33303756
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-020-03174-6
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