A Chemical Signature for Cytidine Acetylation in RNA

N4-acetylcytidine (ac4C) is a highly conserved modified RNA nucleobase whose formation is catalyzed by the disease-associated N-acetyltransferase 10 (NAT10). Here we report a sensitive chemical method to localize ac4C in RNA. Specifically, we characterize the susceptibility of ac4C to borohydride-ba...

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Udgivet i:J Am Chem Soc
Main Authors: Thomas, Justin M., Briney, Chloe A., Nance, Kellie D., Lopez, Jeffrey E., Thorpe, Abigail L., Fox, Stephen D., Bortolin-Cavaille, Marie-Line, Sas-Chen, Aldema, Arango, Daniel, Oberdoerffer, Shalini, Cavaille, Jerome, Andresson, Thorkell, Meier, Jordan L.
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8054311/
https://ncbi.nlm.nih.gov/pubmed/30252461
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.8b06636
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