Acetylation of cytidine in messenger RNA promotes translation efficiency

Generation of the “epitranscriptome” through post-transcriptional ribonucleoside modification embeds a layer of regulatory complexity into RNA structure and function. Here we describe N4-acetylcytidine (ac4C) as an mRNA modification that is catalyzed by the acetyltransferase NAT10. Transcriptome-wid...

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Publicado en:Cell
Main Authors: Arango, Daniel, Sturgill, David M., Alhusaini, Najwa, Dillman, Allissa A., Sweet, Thomas J., Hanson, Gavin, Hosogane, Masaki, Sinclair, Wilson R., Nanan, Kyster K., Mandler, Mariana D., Fox, Stephen D., Zengeya, Thomas T., Andresson, Thorkell, Meier, Jordan L., Coller, Jeffery, Oberdoerffer, Shalini
Formato: Artigo
Idioma:Inglês
Publicado: 2018
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6295233/
https://ncbi.nlm.nih.gov/pubmed/30449621
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2018.10.030
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