Acetylation of cytidine in messenger RNA promotes translation efficiency

Generation of the “epitranscriptome” through post-transcriptional ribonucleoside modification embeds a layer of regulatory complexity into RNA structure and function. Here we describe N4-acetylcytidine (ac4C) as an mRNA modification that is catalyzed by the acetyltransferase NAT10. Transcriptome-wid...

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Veröffentlicht in:Cell
Hauptverfasser: Arango, Daniel, Sturgill, David M., Alhusaini, Najwa, Dillman, Allissa A., Sweet, Thomas J., Hanson, Gavin, Hosogane, Masaki, Sinclair, Wilson R., Nanan, Kyster K., Mandler, Mariana D., Fox, Stephen D., Zengeya, Thomas T., Andresson, Thorkell, Meier, Jordan L., Coller, Jeffery, Oberdoerffer, Shalini
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6295233/
https://ncbi.nlm.nih.gov/pubmed/30449621
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2018.10.030
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