Promoter-interacting expression quantitative trait loci are enriched for functional genetic variants

Expression quantitative trait loci (eQTLs) studies provide associations of genetic variants with gene expression but fall short of pinpointing functionally important eQTLs. Here, using H3K27ac HiChIP assays, we mapped eQTLs overlapping active cis-regulatory elements that interact with their target g...

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Foilsithe in:Nat Genet
Main Authors: Chandra, Vivek, Bhattacharyya, Sourya, Schmiedel, Benjamin J., Madrigal, Ariel, Gonzalez-Colin, Cristian, Fotsing, Stephanie, Crinklaw, Austin, Seumois, Gregory, Mohammadi, Pejman, Kronenberg, Mitchell, Peters, Bjoern, Ay, Ferhat, Vijayanand, Pandurangan
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2020
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8053422/
https://ncbi.nlm.nih.gov/pubmed/33349701
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41588-020-00745-3
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