Promoter-interacting expression quantitative trait loci are enriched for functional genetic variants

Expression quantitative trait loci (eQTLs) studies provide associations of genetic variants with gene expression but fall short of pinpointing functionally important eQTLs. Here, using H3K27ac HiChIP assays, we mapped eQTLs overlapping active cis-regulatory elements that interact with their target g...

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Detalhes bibliográficos
Publicado no:Nat Genet
Main Authors: Chandra, Vivek, Bhattacharyya, Sourya, Schmiedel, Benjamin J., Madrigal, Ariel, Gonzalez-Colin, Cristian, Fotsing, Stephanie, Crinklaw, Austin, Seumois, Gregory, Mohammadi, Pejman, Kronenberg, Mitchell, Peters, Bjoern, Ay, Ferhat, Vijayanand, Pandurangan
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8053422/
https://ncbi.nlm.nih.gov/pubmed/33349701
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41588-020-00745-3
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