Acarbose presents in vitro and in vivo antileishmanial activity against Leishmania infantum and is a promising therapeutic candidate against visceral leishmaniasis

Treatment against visceral leishmaniasis (VL) is mainly hampered by drug toxicity, long treatment regimens and/or high costs. Thus, the identification of novel and low-cost antileishmanial agents is urgent. Acarbose (ACA) is a specific inhibitor of glucosidase-like proteins, which has been used for...

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Библиографические подробности
Опубликовано в: :Med Microbiol Immunol
Главные авторы: Costa, Rafaella R., Oliveira-da-Silva, João A., Reis, Thiago A. R., Tavares, Grasiele S. V., Mendonça, Débora V. C., Freitas, Camila S., Lage, Daniela P., Martins, Vívian T., Antinarelli, Luciana M. R., Machado, Amanda S., Bandeira, Raquel S., Ludolf, Fernanda, Santos, Thaís T. O., Brito, Rory C. F., Humbert, Maria V., Menezes-Souza, Daniel, Duarte, Mariana C., Chávez-Fumagalli, Miguel A., Roatt, Bruno M., Coimbra, Elaine S., Coelho, Eduardo A. F.
Формат: Artigo
Язык:Inglês
Опубликовано: Springer Berlin Heidelberg 2021
Предметы:
Original Investigation
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC8053370/
https://ncbi.nlm.nih.gov/pubmed/33870453
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00430-021-00707-4
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