Acarbose presents in vitro and in vivo antileishmanial activity against Leishmania infantum and is a promising therapeutic candidate against visceral leishmaniasis

Treatment against visceral leishmaniasis (VL) is mainly hampered by drug toxicity, long treatment regimens and/or high costs. Thus, the identification of novel and low-cost antileishmanial agents is urgent. Acarbose (ACA) is a specific inhibitor of glucosidase-like proteins, which has been used for...

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Bibliografiske detaljer
Udgivet i:Med Microbiol Immunol
Main Authors: Costa, Rafaella R., Oliveira-da-Silva, João A., Reis, Thiago A. R., Tavares, Grasiele S. V., Mendonça, Débora V. C., Freitas, Camila S., Lage, Daniela P., Martins, Vívian T., Antinarelli, Luciana M. R., Machado, Amanda S., Bandeira, Raquel S., Ludolf, Fernanda, Santos, Thaís T. O., Brito, Rory C. F., Humbert, Maria V., Menezes-Souza, Daniel, Duarte, Mariana C., Chávez-Fumagalli, Miguel A., Roatt, Bruno M., Coimbra, Elaine S., Coelho, Eduardo A. F.
Format: Artigo
Sprog:Inglês
Udgivet: Springer Berlin Heidelberg 2021
Fag:
Original Investigation
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8053370/
https://ncbi.nlm.nih.gov/pubmed/33870453
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00430-021-00707-4
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