In vitro and in vivo antileishmanial activity of β-acetyl-digitoxin, a cardenolide of Digitalis lanata potentially useful to treat visceral leishmaniasis

Current treatments of visceral leishmaniasis face limitations due to drug side effects and/or high cost, along with the emergence of parasite resistance. Novel and low-cost antileishmanial agents are therefore required. We report herein the antileishmanial activity of β-acetyl-digitoxin (b-AD), a ca...

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發表在:Parasite
Main Authors: Freitas, Camila S., Lage, Daniela P., Oliveira-da-Silva, João A., Costa, Rafaella R., Mendonça, Débora V.C., Martins, Vívian T., Reis, Thiago A.R., Antinarelli, Luciana M.R., Machado, Amanda S., Tavares, Grasiele S.V., Ramos, Fernanda F., Brito, Rory C.F., Ludolf, Fernanda, Chávez-Fumagalli, Miguel A., Roatt, Bruno M., Ramos, Gabriela S., Munkert, Jennifer, Ottoni, Flaviano M., Campana, Priscilla R.V., Duarte, Mariana C., Gonçalves, Denise U., Coimbra, Elaine S., Braga, Fernão C., Pádua, Rodrigo M., Coelho, Eduardo A.F.
格式: Artigo
語言:Inglês
出版: EDP Sciences 2021
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC8045677/
https://ncbi.nlm.nih.gov/pubmed/33851916
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1051/parasite/2021036
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