In vitro and in vivo antileishmanial activity of β-acetyl-digitoxin, a cardenolide of Digitalis lanata potentially useful to treat visceral leishmaniasis

Current treatments of visceral leishmaniasis face limitations due to drug side effects and/or high cost, along with the emergence of parasite resistance. Novel and low-cost antileishmanial agents are therefore required. We report herein the antileishmanial activity of β-acetyl-digitoxin (b-AD), a ca...

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Опубликовано в: :Parasite
Главные авторы: Freitas, Camila S., Lage, Daniela P., Oliveira-da-Silva, João A., Costa, Rafaella R., Mendonça, Débora V.C., Martins, Vívian T., Reis, Thiago A.R., Antinarelli, Luciana M.R., Machado, Amanda S., Tavares, Grasiele S.V., Ramos, Fernanda F., Brito, Rory C.F., Ludolf, Fernanda, Chávez-Fumagalli, Miguel A., Roatt, Bruno M., Ramos, Gabriela S., Munkert, Jennifer, Ottoni, Flaviano M., Campana, Priscilla R.V., Duarte, Mariana C., Gonçalves, Denise U., Coimbra, Elaine S., Braga, Fernão C., Pádua, Rodrigo M., Coelho, Eduardo A.F.
Формат: Artigo
Язык:Inglês
Опубликовано: EDP Sciences 2021
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Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC8045677/
https://ncbi.nlm.nih.gov/pubmed/33851916
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1051/parasite/2021036
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