A candidate vaccine for human visceral leishmaniasis based on a specific T cell epitope-containing chimeric protein protects mice against Leishmania infantum infection

Leishmaniases are neglected diseases caused by infection with Leishmania parasites and there are currently no prophylactic vaccines. In this study, we designed in silico a synthetic recombinant vaccine against visceral leishmaniasis (VL) called ChimeraT, which contains specific T-cell epitopes from...

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Bibliographic Details
Published in:NPJ Vaccines
Main Authors: Lage, Daniela P., Ribeiro, Patrícia A. F., Dias, Daniel S., Mendonça, Débora V. C., Ramos, Fernanda F., Carvalho, Lívia M., de Oliveira, Daysiane, Steiner, Bethina T., Martins, Vívian T., Perin, Luísa, Machado, Amanda S., Santos, Thaís T. O., Tavares, Grasiele S. V., Oliveira-da-Silva, João A., Oliveira, Jamil S., Roatt, Bruno M., Machado-de-Ávila, Ricardo A., Teixeira, Antônio L., Humbert, Maria V., Coelho, Eduardo A. F., Christodoulides, Myron
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2020
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7426426/
https://ncbi.nlm.nih.gov/pubmed/32821440
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41541-020-00224-0
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