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Systematic in vitro specificity profiling reveals nicking defects in natural and engineered CRISPR–Cas9 variants
Cas9 is an RNA-guided endonuclease in the bacterial CRISPR–Cas immune system and a popular tool for genome editing. The commonly used Streptococcus pyogenes Cas9 (SpCas9) is relatively non-specific and prone to off-target genome editing. Other Cas9 orthologs and engineered variants of SpCas9 have be...
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| Pubblicato in: | Nucleic Acids Res |
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| Autori principali: | , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Oxford University Press
2021
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8053117/ https://ncbi.nlm.nih.gov/pubmed/33744974 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkab163 |
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